Comparison of wild-type L4 stage larva (right) and a sibling the same age (left) with a single copy ribosomal protein gene loss.

Comparison of wild-type L4 stage larva (right) and a sibling the same age (left) with a single copy ribosomal protein gene loss.

PROTEiN TRANSLATION

How is ribosome biogenesis and cell & organism growth/differentiation connected?

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Checkpoint arrest in ribosome deficiency

What is the mechanism of checkpoint arrest in larvae that are mixture of ribosome competent and incompetent cells?

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ribosomal RNA & nucleolus

Developing systems level approaches to understand the function of ribosomal RNA and nucleolus

 

Relevant publications:

(Use the pubmed link to see all publications)

Cenik ES, Meng X, Tang NH ,Hall RN, Arribere JA, Cenik C, Jin Y, Fire AZ (2019). Maternal ribosomes are sufficient for tissue diversification during embryonic development in C. elegans. Developmental Cell, Mar25;48(6), 811-826.e6. doi:10.1016/j.devcel.2019.01.019, highlighted in the same issue with a preview by Haag and Dinman, 2019, Featured in Faculty of 1000.

Arribere, JA, Cenik ES, Jain N, Hess G, Lee C, Bassik MC, Fire AF. (2016). Translation Readthrough Mitigation. Nature, Jun 1;534(7609):719-723. doi: 10.1038/nature18308.

Cenik C, Cenik ES, Byeon GW, Grubert F, Candille S, Spacek D, Alsallakh B, Tilgner H, Araya CL, Tang H, Ricci E, Snyder MP. (2015). Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans. Genome Research, Nov;25(11):1610-21. doi: 10.1101/gr.193342.115.